@import url('https://fonts.googleapis.com/css2?family=Outfit:wght@300;400;500;600;700;800&family=Plus+Jakarta+Sans:wght@300;400;500;600;700&display=swap');

:root {
  --bg-primary: #090a15;
  --bg-secondary: #111322;
  --accent-teal: #10b981;
  --accent-cyan: #06b6d4;
  --accent-purple: #8b5cf6;
  --text-primary: #f8fafc;
  --text-secondary: #94a3b8;
  --text-muted: #64748b;
  --glass-bg: rgba(17, 25, 40, 0.55);
  --glass-border: rgba(255, 255, 255, 0.08);
  --glass-shadow: rgba(0, 0, 0, 0.4);
}

* {
  box-sizing: border-box;
  margin: 0;
  padding: 0;
}

body.biomodifying-body {
  background: radial-gradient(circle at 50% 0%, #1e1b4b 0%, #090a16 70%);
  color: var(--text-primary);
  font-family: 'Plus Jakarta Sans', sans-serif;
  line-height: 1.6;
  min-height: 100vh;
}

h1, h2, h3, h4 {
  font-family: 'Outfit', sans-serif;
  font-weight: 600;
  letter-spacing: -0.02em;
}

a {
  color: var(--accent-cyan);
  text-decoration: none;
  transition: all 0.2s ease-in-out;
}

a:hover {
  color: var(--accent-teal);
}

/* Glassmorphism Styles */
.glass-panel, .sidebar-card, .glass-card {
  background: var(--glass-bg);
  backdrop-filter: blur(12px);
  -webkit-backdrop-filter: blur(12px);
  border: 1px solid var(--glass-border);
  border-radius: 1rem;
  box-shadow: 0 8px 32px 0 var(--glass-shadow);
  padding: 1.75rem;
}

/* Site Header */
.site-header {
  position: sticky;
  top: 0;
  z-index: 100;
}

.header-glass-wrapper {
  background: rgba(9, 10, 21, 0.7);
  backdrop-filter: blur(16px);
  -webkit-backdrop-filter: blur(16px);
  border-bottom: 1px solid var(--glass-border);
}

.header-container {
  max-width: 1200px;
  margin: 0 auto;
  padding: 1rem 2rem;
  display: flex;
  justify-content: space-between;
  align-items: center;
}

.site-logo {
  display: flex;
  align-items: center;
  gap: 0.75rem;
}

.logo-icon {
  font-size: 2rem;
  animation: float-dna 4s ease-in-out infinite;
}

.logo-title {
  display: block;
  font-family: 'Outfit', sans-serif;
  font-size: 1.5rem;
  font-weight: 700;
  color: var(--text-primary);
  background: linear-gradient(135deg, var(--text-primary) 0%, var(--accent-cyan) 100%);
  -webkit-background-clip: text;
  -webkit-text-fill-color: transparent;
}

.logo-subtitle {
  display: block;
  font-size: 0.75rem;
  color: var(--text-secondary);
  text-transform: uppercase;
  letter-spacing: 0.1em;
}

.site-nav .nav-links {
  display: flex;
  list-style: none;
  gap: 1.5rem;
}

.nav-link {
  font-family: 'Outfit', sans-serif;
  font-size: 0.95rem;
  font-weight: 500;
  color: var(--text-secondary);
  padding: 0.5rem 1rem;
  border-radius: 0.5rem;
  transition: all 0.2s ease;
}

.nav-link:hover {
  color: var(--text-primary);
  background: rgba(255, 255, 255, 0.05);
}

/* Hero Section */
.hero-section {
  position: relative;
  padding: 8rem 2rem 6rem;
  text-align: center;
  overflow: hidden;
}

.hero-overlay {
  position: absolute;
  top: 0;
  left: 0;
  right: 0;
  bottom: 0;
  background: radial-gradient(circle at center, rgba(139, 92, 246, 0.15) 0%, transparent 60%);
  z-index: 1;
}

.hero-container {
  position: relative;
  z-index: 2;
  max-width: 800px;
  margin: 0 auto;
}

.hero-badge {
  display: inline-block;
  padding: 0.4rem 1rem;
  background: rgba(6, 182, 212, 0.1);
  border: 1px solid rgba(6, 182, 212, 0.2);
  border-radius: 2rem;
  font-size: 0.8rem;
  font-weight: 600;
  color: var(--accent-cyan);
  text-transform: uppercase;
  letter-spacing: 0.05em;
  margin-bottom: 1.5rem;
}

.hero-title {
  font-size: 3.5rem;
  line-height: 1.15;
  font-weight: 800;
  margin-bottom: 1.5rem;
  background: linear-gradient(135deg, #ffffff 0%, #cbd5e1 50%, var(--accent-cyan) 100%);
  -webkit-background-clip: text;
  -webkit-text-fill-color: transparent;
}

.hero-tagline {
  font-size: 1.15rem;
  color: var(--text-secondary);
  margin-bottom: 2.5rem;
  max-width: 650px;
  margin-left: auto;
  margin-right: auto;
}

.hero-ctas {
  display: flex;
  justify-content: center;
  gap: 1rem;
}

.btn {
  display: inline-block;
  padding: 0.75rem 1.75rem;
  border-radius: 0.75rem;
  font-family: 'Outfit', sans-serif;
  font-weight: 600;
  font-size: 0.95rem;
  transition: all 0.2s ease-in-out;
}

.btn-primary {
  background: linear-gradient(135deg, var(--accent-cyan) 0%, var(--accent-teal) 100%);
  color: #090a15;
  box-shadow: 0 4px 20px rgba(6, 182, 212, 0.35);
}

.btn-primary:hover {
  transform: translateY(-2px);
  box-shadow: 0 6px 24px rgba(6, 182, 212, 0.45);
}

.btn-outline {
  border: 1px solid var(--glass-border);
  background: rgba(255, 255, 255, 0.03);
  color: var(--text-primary);
}

.btn-outline:hover {
  background: rgba(255, 255, 255, 0.08);
  border-color: var(--text-secondary);
}

/* Layout Grid */
.main-layout-container {
  max-width: 1200px;
  margin: 0 auto;
  padding: 3rem 2rem;
}

.layout-grid {
  display: grid;
  grid-template-columns: 2fr 1fr;
  gap: 2.5rem;
}

/* Main Article Content */
.main-article {
  background: var(--glass-bg);
  border: 1px solid var(--glass-border);
  border-radius: 1.25rem;
  padding: 3rem;
  box-shadow: 0 8px 32px 0 var(--glass-shadow);
}

.article-header {
  margin-bottom: 2rem;
  border-bottom: 1px solid var(--glass-border);
  padding-bottom: 1.5rem;
}

.article-meta {
  display: flex;
  gap: 1.5rem;
  font-size: 0.85rem;
  color: var(--text-secondary);
  margin-bottom: 0.75rem;
}

.meta-item.category {
  color: var(--accent-cyan);
  font-weight: 600;
  text-transform: uppercase;
  letter-spacing: 0.05em;
}

.article-title {
  font-size: 2.5rem;
  line-height: 1.2;
}

/* Content HTML Formatting */
.article-content h2 {
  font-size: 1.75rem;
  color: #ffffff;
  margin: 2.5rem 0 1rem;
}

.article-content h3 {
  font-size: 1.35rem;
  color: var(--accent-cyan);
  margin: 1.75rem 0 0.75rem;
}

.article-content p {
  color: var(--text-secondary);
  margin-bottom: 1.25rem;
  font-size: 1.05rem;
  line-height: 1.7;
}

.article-content ul, .article-content ol {
  margin-bottom: 1.5rem;
  padding-left: 1.5rem;
  color: var(--text-secondary);
}

.article-content li {
  margin-bottom: 0.5rem;
}

.article-footer {
  margin-top: 3.5rem;
  border-top: 1px solid var(--glass-border);
  padding-top: 1.5rem;
}

.reference-note {
  font-size: 0.85rem;
  color: var(--text-muted);
  margin-top: 0.5rem;
}

/* Pipeline Table */
.pipeline-table {
  width: 100%;
  border-collapse: collapse;
  margin: 1.5rem 0;
  text-align: left;
}

.pipeline-table th, .pipeline-table td {
  padding: 1rem;
  border-bottom: 1px solid var(--glass-border);
}

.pipeline-table th {
  font-family: 'Outfit', sans-serif;
  color: #ffffff;
  font-weight: 600;
  background: rgba(255, 255, 255, 0.02);
}

.status-badge {
  display: inline-block;
  padding: 0.25rem 0.75rem;
  border-radius: 2rem;
  font-size: 0.75rem;
  font-weight: 700;
  text-transform: uppercase;
}

.status-badge.phase1 {
  background: rgba(6, 182, 212, 0.1);
  color: var(--accent-cyan);
  border: 1px solid rgba(6, 182, 212, 0.2);
}

.status-badge.preclinical {
  background: rgba(245, 158, 11, 0.1);
  color: #f59e0b;
  border: 1px solid rgba(245, 158, 11, 0.2);
}

.status-badge.phase2 {
  background: rgba(16, 185, 129, 0.1);
  color: var(--accent-teal);
  border: 1px solid rgba(16, 185, 129, 0.2);
}

.status-badge.IND {
  background: rgba(139, 92, 246, 0.1);
  color: var(--accent-purple);
  border: 1px solid rgba(139, 92, 246, 0.2);
}

/* Form Styles */
.form-group {
  margin-bottom: 1.25rem;
}

.form-group label {
  display: block;
  font-size: 0.85rem;
  font-weight: 600;
  color: var(--text-secondary);
  margin-bottom: 0.5rem;
  text-transform: uppercase;
  letter-spacing: 0.05em;
}

.form-group input, .form-group textarea {
  width: 100%;
  background: rgba(9, 10, 21, 0.6);
  border: 1px solid var(--glass-border);
  border-radius: 0.75rem;
  padding: 0.75rem 1rem;
  color: #ffffff;
  outline: none;
  font-family: inherit;
  transition: all 0.2s ease;
}

.form-group input:focus, .form-group textarea:focus {
  border-color: var(--accent-cyan);
  background: rgba(9, 10, 21, 0.8);
  box-shadow: 0 0 0 2px rgba(6, 182, 212, 0.2);
}

/* Sidebar styling */
.site-sidebar {
  display: flex;
  flex-direction: column;
  gap: 2rem;
}

.sidebar-card h3 {
  font-size: 1.25rem;
  margin-bottom: 1rem;
  border-bottom: 1px solid var(--glass-border);
  padding-bottom: 0.5rem;
  color: #ffffff;
}

.sidebar-card p {
  color: var(--text-secondary);
  font-size: 0.95rem;
}

.card-badge {
  display: inline-block;
  padding: 0.25rem 0.6rem;
  background: rgba(139, 92, 246, 0.15);
  border: 1px solid rgba(139, 92, 246, 0.2);
  border-radius: 0.5rem;
  font-size: 0.75rem;
  font-weight: 700;
  color: #a78bfa;
  margin-bottom: 0.75rem;
}

.sidebar-links {
  list-style: none;
  display: flex;
  flex-direction: column;
  gap: 1rem;
}

.sidebar-link {
  display: flex;
  align-items: flex-start;
  gap: 0.75rem;
}

.link-bullet {
  color: var(--accent-cyan);
  font-size: 0.9rem;
  margin-top: 0.15rem;
}

.link-title {
  display: block;
  font-weight: 500;
  font-size: 0.95rem;
  color: var(--text-secondary);
  line-height: 1.35;
}

.sidebar-link:hover .link-title {
  color: var(--accent-teal);
}

.link-date {
  display: block;
  font-size: 0.75rem;
  color: var(--text-muted);
  margin-top: 0.25rem;
}

.benefit-list {
  list-style: none;
  display: flex;
  flex-direction: column;
  gap: 0.75rem;
  font-size: 0.9rem;
  color: var(--text-secondary);
}

/* Site Footer */
.site-footer {
  background: rgba(9, 10, 21, 0.9);
  border-top: 1px solid var(--glass-border);
  padding: 4rem 2rem 2rem;
  margin-top: 6rem;
}

.footer-container {
  max-width: 1200px;
  margin: 0 auto;
  display: grid;
  grid-template-columns: 2fr 1fr 1fr;
  gap: 4rem;
  padding-bottom: 3rem;
  border-bottom: 1px solid var(--glass-border);
}

.footer-col h4 {
  font-size: 1.15rem;
  color: #ffffff;
  margin-bottom: 1.25rem;
}

.footer-col p {
  color: var(--text-secondary);
  font-size: 0.95rem;
}

.footer-col ul {
  list-style: none;
  display: flex;
  flex-direction: column;
  gap: 0.75rem;
}

.footer-col a {
  color: var(--text-secondary);
  font-size: 0.95rem;
}

.footer-col a:hover {
  color: var(--accent-cyan);
}

.footer-bottom {
  max-width: 1200px;
  margin: 2rem auto 0;
  display: flex;
  justify-content: space-between;
  align-items: center;
  font-size: 0.85rem;
  color: var(--text-muted);
}

/* Animations */
@keyframes float-dna {
  0%, 100% {
    transform: translateY(0) rotate(0deg);
  }
  50% {
    transform: translateY(-5px) rotate(15deg);
  }
}

/* Responsive adjustments */
@media (max-width: 900px) {
  .layout-grid {
    grid-template-columns: 1fr;
  }
  .hero-title {
    font-size: 2.5rem;
  }
  .footer-container {
    grid-template-columns: 1fr;
    gap: 2rem;
  }
}